The CUE1+ is primarily designed to address motor symptoms, and most clinical evidence focuses on improvements in movement, gait, rigidity, and balance. However, emerging data from our research studies, including a pilot study and a double-blind RCT by Azoidou et al. (2025), suggest that benefits may extend beyond motor function. Participants in these studies reported improvements in quality of life and sleep, as well as fewer medication-related complications.  

There are plausible mechanistic reasons for these broader effects. The CUE1+ is worn at the sternum, which research suggests could indirectly stimulate the vagus nerve, a pathway involved in regulating the autonomic nervous system, including heart rate, digestion, and emotional state. The device also delivers vibrotactile stimulation at a frequency near the resting heart rate, which studies indicate may have a calming effect and reduce anxiety. Since increased anxiety is known to worsen motor symptoms in Parkinson’s, reducing it may contribute to the observed motor improvements as well as broader well-being benefits. 

These non-motor findings are preliminary and require further investigation.