The CUE1+ is a non-invasive device and is generally very well tolerated. Across our clinical studies to date, no serious side effects have been reported. 

In the published pilot study by Azoidou et al. (Queen Mary University of London, 2025), no side effects were reported across the nine-week study period, including from the adhesive patches. In the double-blind RCT (Azoidou et al., 2025, preprint), mild, transient skin irritation at the adhesive patch site occurred in 2 of 50 participants (4%), resolving without treatment. No other adverse events were attributed to the device. 

As with any wearable worn against the skin, a small number of users may notice mild sensitivity or localised irritation at the adhesive site. Ensuring the skin is clean and dry before application and rotating the placement site slightly when replacing the patches can help minimise discomfort. If you experience any persistent irritation or unexpected reactions, we recommend removing the device and contacting our support team or your clinician for advice. 

We are committed to transparency about our device’s safety profile. If you would like to share clinical information with your GP or specialist before starting, we are happy to provide this. Simply get in touch.