THE SCIENCE

SIMPLE TECHNOLOGY, BIG IMPACT

DEVELOPED BY NEUROSCIENTISTS, DOCTORS & ENGINEERS

THE SCIENCE BEHIND CUE1

CUE1 is a non-invasive wearable device for Parkinson’s that relieves movement symptoms like slowness and stiffness while sitting on the sternum, but how does it work?

CUE1 uses a quiet electric motor to produce vibrotactile stimulation. The vibrations are produced in a specialised pattern developed through extensive research and testing with people with Parkinson’s. Through the pattern’s wave shape and frequency, the device delivers two scientifically validated non-invasive Parkinson’s therapies in a combination unique to this device; focused stimulation and cueing. While the precise mechanisms by which these therapies work to improve movement symptoms in Parkinson’s is not completely understood, the scientific literature, as well as our own user testing, demonstrates their efficacy.

FOCUSED STIMULATION FOR PARKINSON’S

This phenomenon was first described in the 19th century when Professor Jean-Martin Charcot noticed an improvement in his Parkinson’s patients after a bumpy carriage ride.

More recent research into the effect of sensory stimulation on the movement symptoms of Parkinson’s has improved our understanding. When used correctly, some forms of specific sensory stimulation, such as the vibration administered by CUE1, can interfere with neurological processes that are thought to impede movement in Parkison’s.

Please see the description of focused stimulation by our expert advisor, Dr Sweta Adatia, for a more detailed explanation.

CUEING FOR PARKINSON’S

Another established phenomenon of Parkinson’s treatment that CUE11 employs is, of course, that of cueing, which is achieved by pulsing the vibrations.

There are many anecdotal and scientific examples of the benefits of cue signs of various modalities in Parkinson’s, from the sound of a metronome to visuals cues like lines on the floor.

The main benefit cueing provides for people with Parkinson’s is a reduction in freeze-of-gait episodes, leading to smoother overall movement in people with Parkinson’s. 

DEVELOPING FOR PARKINSON’S

CUE1 has been developed in close collaboration with people with Parkinson’s, ensuring the theory that we see in the scientific literature and learn about from our scientific and medical advisors provides real benefit in practice.

Through this process, we have arrived at the placement of the device and characteristics of the stimulation that resulted in the most consistent benefit across all our user testers.

However, we are very aware that everybody’s Parkinson’s is different and therefore have designed CUE1 so that you can experiment with both of these factors to find the combination that best suits you.

INTERESTED IN TRIALING OUR DEVICE WITH YOUR PARKINSON'S PATIENTS?

We’d love to hear from you if you work with people with Parkinson’s and would like to trial our device.

HELPING TO BETTER MANAGE PARKINSON'S

DISCREET MEDICATION REMINDERS

The CUE1 device was originally developed to ease symptoms of Parkinson’s, but during our initial testing phase, our participants informed us of the difficulties associated with taking medication on time and asked us if there was any way that the device could help.

Taking medication at the correct times is vital to manage symptoms and get the most out of medication for Parkinson’s.

To help people with Parkinson’s remember to take their medication we have integrated this feature into the device.

Medication reminders are set up via our easy-to-use application and are given by a discreet vibration from the device, so patients don’t experience the inconvenience of having to acknowledge reminders on their phone.

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